GlycoThera Pharmaceutical Services is a leading global service provider for contract development and analytics for biotherapeutics at all stages of product life cycle. With our expertise in the development of biologics (recombinant proteins such as monoclonal antibodies, cytokines and hormones), manufacturing sciences, analytics, quality control and regulatory strategy we support a broad range of clients globally, from emerging biotech startups to leading global pharmaceutical companies. 

For our site in Julich (Germany) we are looking for several highly motivated scientists to join our Upstream Process Development team. The main area of responsibility will be the development of upstream processes intended for the manufacture of recombinant proteins under GMP.

The Julich site focusses on small-scale process development for the manufacture of recombinant proteins up to readiness for transfer into pilot scale. Our well-equipped laboratories as well as established high-class analytical infrastructure support targeted, high-throughput development. At the same time, we are striving for innovative and efficient approaches to process development and welcome fresh thinking combined with solid skills. You will be part of a team that values respect, trust, reliability and positivity.

• Independent planning, execution and documentation of small-scale mammalian cell culture processes (15 mL to 10 L)
• Adequate documentation of all work
• Application of quality by design principles to achieve project goals like specific product quality profiles or enhanced process yields
• Evaluation of cell culture process as well as product quality results against agreed targets to plan subsequent project steps
• Presentation of main results and project status in internal meetings  
• Support of Tech Transfer of small-scale processes to the customer (technical documentation and potentially on-site support)
• Maintenance of databases and data mining
• Training and supervision of lab technicians
• Support the team with occasional weekend duties

Required experience:

• Master in Biotechnology, Biology or other relevant education with several years of work experience in the area of upstream process development (mammalian cell culture)
• End-to-end understanding and hands-on expertise of upstream process from vial thaw to harvest clarification
• Sound understanding of major steps involved in the development of a biopharmaceutical (process development, process lock, scale-up, tech transfer and process characterization, process validation)
• Hands-on experience with common fermentation systems like ambr™15, ambr™250, Wave bioreactor, 10 L bioreactor (glass vessel, single use), incl. related software
• Sound statistical knowledge and experienced in the use of statistical software like JMP and MODDE, SIMCA 
• Ideally experienced in protein characterization
• Familiar with common quality principles (GMP, ISO:9001, ALCOA)

• You are a smart, proactive and solution-driven scientist with a hands-on attitude who is able to independently progress projects, prioritize tasks adequately and work against tight timelines. At the same time you maintain a high quality standard in your work, support the team and foster a sense of positivity. The team´s success is your success.

   

  Language: English, German is highly beneficial.

   

  Experience: Industrial work experience (biotechnology/biopharma) is highly appreciated.

Our Julich site with currently 40 employees offers an innovative, vibrant and multicultural environment that gives you the chance to bring in all of your competencies, and together with a highly motivated team drive the change and develop personally. We believe in a culture of respect, trust, reliability and positivity.

Interested? Then please send us your full application as PDF including earliest start date and salary expectations.

Glycothera Development GmbH 
 Karl-Heinz-Beckurts-Str. 13 
 52428 Jülich 

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